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FACTOR XIIA
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DeCS
Descriptor
English
:
Factor XIIa
Descriptor
Spanish
:
Factor XIIa
Descriptor
Portuguese
:
Fator XIIa
Synonyms
English
:
Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Fragments, Hageman-Factor
Hageman Factor Fragments
Hageman-Factor Fragments
Prekallikrein Activator
Tree Number:
D08.811.277.656.300.760.324
D08.811.277.656.959.350.324
D12.776.124.125.450.324
D23.119.450.324
Definition
English
:
Activated form of
factor XII
. In the initial event in the intrinsic pathway of
blood coagulation
, kallikrein (with cofactor HIGH
MOLECULAR WEIGHT
KININOGEN) cleaves
factor XII
to XIIa.
Factor XIIa
is then further cleaved by kallikrein, plasmin, and
trypsin
to yield smaller
factor XII
fragments (Hageman-Factor fragments). These fragments increase the activity of
prekallikrein
to kallikrein but decrease the procoagulant activity of
factor XII.
Indexing Annotation
English
:
/defic =
FACTOR XII DEFICIENCY
See Related
English
:
Coagulants
History Note
English
:
90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24648
Unique Identifier:
D015956
Occurrence in VHL
:
Similar:
DeCS